Controlling monomer-sequence using supramolecular templates

Controlling monomer-sequence using supramolecular templates

The monomer sequences in biopolymers such as nucleic acids and proteins are strongly linked to their function, and even small errors can yield non-functional macromolecules, or worse. Nature therefore expends significant resources on the (nearly) flawless synthesis of these polymers. For example, DNA is replicated using DNA polymerases, which achieve error rates as low as 1 in 10 nucleotide add...

Supramolecular polymer nanofibers via electrospinning of a heteroditopic monomer.

Driven by the benzo-21-crown-7/secondary ammonium salt recognition motif, a linear supramolecular polymer was formed from self-organization of a low-molecular-weight self-complementary monomer in chloroform. From this supramolecular polymer, nanofibers were obtained successfully via electrospinning.

A selectivity-driven supramolecular polymerization of an AB monomer.

Controlling molecular tautomerism through supramolecular selectivity.

We have isolated the stable as well as the metastable tautomers of 1-deazapurine in the solid state by exploiting principles of supramolecular selectivity in the context of cocrystal design.

Novel supramolecular affinity materials based on (−)-isosteviol as molecular templates

The readily available ex-chiral-pool building block (-)-isosteviol was combined with the C 3-symmetric platforms hexahydroxytriphenylene and hexaaminotriptycene providing large and rigid molecular architectures. Because of the persistent cavities these scaffolds are very potent supramolecular affinity materials for head space analysis by quartz crystal microbalances. The scaffolds serve in part...